Dacarbazine mediates antimelanoma effects via NK cells

Dacarbazine mediates antimelanoma effects via NK cells

Melanoma is a highly chemoresistant and metastatic tumor that, in the absence of BRAF mutations, is generally treated with the alkylating agent dacarbazine (DTIC). We discovered that DTIC upregulates the expression of NKG2D ligands on tumor cells, leading to the activation of natural killer (NK) and CD8+ T cells. These observations underscore the immunogenic properties of DTIC and provide a rat...

Signal Transduction Neurotransmitter Substance P Mediates Pancreatic Cancer Perineural Invasion via NK-1R in Cancer Cells

Pancreatic cancer significantly affects the quality of life due to the severe abdominal pain. However, the underlying mechanism is not clear. This study aimed to determine the relationship between Substance P (SP) and pancreatic cancer perineural invasion (PNI) as well as themechanism of SPmediating pancreatic cancer PNI, which causes pain in patients with pancreatic cancer. Human pancreatic ca...

Neighboring Intraepithelial NK Cells Epithelial Cell Death Via the Activation of Autocrine IL-15 Mediates Intestinal

Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells.

Pancreatic cancer significantly affects the quality of life due to the severe abdominal pain. However, the underlying mechanism is not clear. This study aimed to determine the relationship between Substance P (SP) and pancreatic cancer perineural invasion (PNI) as well as the mechanism of SP mediating pancreatic cancer PNI, which causes pain in patients with pancreatic cancer. Human pancreatic ...

Autocrine IL-15 mediates intestinal epithelial cell death via the activation of neighboring intraepithelial NK cells.

Intestinal intraepithelial lymphocytes (IELs), which reside between the basolateral faces of intestinal epithelial cells (IECs), provide a first-line defense against pathogens via their cytotoxic activity. Although IEC-derived IL-7 and IL-15 are key regulatory cytokines for the development and activation of IELs, we report here that IL-15 but not IL-7 mediates the reciprocal interaction between...